Structural evaluations of tau protein conformation: methodologies and approaches
نویسندگان
چکیده
منابع مشابه
Global Conformation of Tau Protein Mapped by Raman Spectroscopy.
Alzheimer's disease (AD) is one of the neurodegenerative disease characterized by progressive neuronal loss in the brain. Its two major hallmarks are extracellular senile plaques and intracellular neurofibrillary tangles (NFTs), formed by aggregation of amyloid β-42 (Aβ-42) and Tau protein respectively. Aβ-42 is a transmembrane protein, which is produced after the sequential action of β- and γ-...
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ژورنال
عنوان ژورنال: Biochemistry and Cell Biology
سال: 2017
ISSN: 0829-8211,1208-6002
DOI: 10.1139/bcb-2016-0227